simshape 2.0.0 © 2001,2008 by Turku PET Centre
Simulates the time-activity curves (TACs) of authentic, Cs(t), and
metabolized, Cm(t), radiotracer using the measured total tissue curve,
Ct(t), and rate constant k3, based on the shape analysis method (1,2).
1) Tissue TAC file
3) Filename for simulated Cm(t)
-h or --help
Print this message and exit
Interpolated regional TACs are written in DFT format.
--version or --build
Print software build information and exit
Program works silently, printing only error and warning messages
Program prints lots of information about what it is doing.
Format of the TAC data are specified in
Example: metabolite TAC in tissue is simulated first, saving also the
fitted and interpolated total tissue TAC, then the TAC of
authentic tracer is calculated by subtraction, and finally all curves
are plotted in SVG format:
simshape -int=ua1309ct.dft ua1309.dft 0.070 ua1309cm.dft
taccalc ua1309ct.dft - ua1309cm.dft ua1309cs.dft
tac2svg ua1309sa.svg -s ua1309.dft -l ua1309ct.dft ua1309cs.dft ua1309cm.dft
1. Koeppe RA, Frey KA, Snyder SE, Meyer P, Kilbourn MR, Kuhl DE.
Kinetic modeling of N-[11C]methylpiperidin-4-yl propionate: alternatives
for analysis of an irreversible positron emission tomography tracer for
measurement of acetylcholinesterase activity in human brain.
J Cereb Blood Flow Metab. 1999;19:1150-1163.
2. Tanaka N, Fukushi K, Shinotoh H, Nagatsuka S, Namba H, Iyo M, Aotsuka A,
Ota T, Tanada S, Irie T. Positron emission tomographic measurement of
brain acetylcholinesterase activity using N-[11C]methylpiperidin-4-yl
acetate without arterial blood sampling: methodology of shape analysis
and its diagnostic power for Alzheimer's disease.
J Cereb Blood Flow Metab. 2001;21:295-306.
See also: fitshape
Keywords: DFT, simulation, reference input, enzyme activity, shape analysis
This program comes with ABSOLUTELY NO WARRANTY. This is free software, and
you are welcome to redistribute it under GNU General Public License.