fith2met 0.1.0 © 2009 Turku PET Centre

Fits the Hill type function to plasma fraction curves of parent tracer and two metabolites. Functions fitted are: Parent (unchanged) fraction: f(x) = 1 - (A*x^B)/(C+x^B) Metabolite 1 fraction: f(x) = (f1*A*x^B)/(C+x^B) Metabolite 2 fraction: f(x) = ((1-f1)*A*x^B)/(C+x^B) , where 0<A<=1 , B>0 , C>0 Usage: fith2met [Options] <Fraction file> [Fit file] General options: -nd Some fractions are known to exceed 1, not divided by 100. -h or --help Print this message and exit. --build or --version Print software build information and exit. --silent Program works silently, printing only error and warning messages. --verbose Program prints more information about what it is doing. Options to set weights: -W1 All weights are set to 1.0; by default, sample times are used to calculate weights unless weights are supplied in fraction file. Fraction datafile must contain 3-4 columns, that is, sample times and fractions of parent tracer and at least metabolite 1. Weights can be specified as specified in DFT format (3); any additional columns are ignored. Lines that start with a '#' are not read from the datafile. Program writes the fit start and end times, nr of points, WSS/n, and parameters of the fitted function to the result (fit) file (4). References: 1. Fitting the fractions of parent tracer in plasma. http://www.turkupetcentre.net/analysis/doc/fraction_fit.html 2. Wu S, Ogden RT, Mann JJ, Parsey RV. Optimal metabolite curve fitting for kinetic modeling of 11C-WAY-100635. J Nucl Med 2007;48:926-931. 3. DFT format. http://www.turkupetcentre.net/analysis/doc/format_dft.html 4. FIT format. http://www.turkupetcentre.net/analysis/doc/format_fit.html See also: fit2dat, metabcor, avgfract, fit_sigm, fit_fexp, fit_hill, dft2svg Keywords: input, modelling, simulation, metabolite correction This program comes with ABSOLUTELY NO WARRANTY. This is free software, and you are welcome to redistribute it under GNU General Public License.