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Autoradiography


The most common implementation of autoradiography in PET is the estimation of perfusion.


Autoradiography in the estimation of tissue perfusion with [15O]H2O


Autoradiography has been used to quantitate the regional perfusion of the brain and skeletal muscle. The method has been validated for skeletal muscle in Turku [Ruotsalainen et al 1997]. The two-compartmental model is assumed to describe the accumulation and efflux of labeled water.

pic/perfusion.gif (15262 bytes)

The partition coefficient (p=K1/k2) is assumed to be known. The measured blood curve and model are used to simulate tissue curves with different perfusion values. These simulated tissue curves are integrated over a specified time. The integral values from measured static PETimages are compared pixel-by-pixel to the simulated integrals and the corresponding perfusion values are written in a parametric image.

pic/perfusion_arg.gif (13662 bytes)


Ruotsalainen U, Raitakari M, Nuutila P, Oikonen V, Sipilä H, Teräs M, Knuuti J, Bloomfield PM, Iida H. Quantitative blood flow measurement of skeletal muscle using oxygen-15-water and PET. J Nucl Med 1997; 38:314-319.