Distributed models

Distributed models describe spatial and temporal variations variations and are generally accepted to correspond more closely to physiological reality than simpler compartment models (Zierler 1981, Kuikka et al 1991). Compartment models are inadequate when the data have high temporal resolution (Zierler 1981). However, in PET imaging, compartment models have been shown to provide estimates of receptor concentration that are as good as those of a distributed model, and are assumed to be adequate for analysis of PET imaging data in general, when there is limited temporal resolution (Muzic & Saidel, 2003).

Kuikka JT, Bassingthwaighte JB, Henrich MM, Feinendegen LE. Mathematical modelling in nuclear medicine. Eur J Nucl Med 1991; 18: 351-362.

Muzic RF Jr, Saidel GM. Distributed versus compartmental models for PETreceptor studies. IEEE Trans Med Imag 2003; 22:11-21.

Zierler K. A critique of compartmental analysis. Annu Rev Biophys Bioeng 1981; 10:531-562.