Quantification of A1R
with [11C]MPDX
Background
Adenosine acts as an endogenous modulator of synaptic functions in
the nervous system. The effects are mediated by at least 4 adenosine receptor
subtypes: A1, A2A, A2B, and A3.
A1Rs inhibit adenylyl cyclase and they are G protein linked.
A2AR can be studied with PET with
[11C]MPDX.
Suggested analysis method for Turku
Brain
Logan plot with arterial metabolite corrected plasma input function is
recommended, with linear fitting from 10 min to at least 35-40 min after
injection (Kimura et al., 2004).
References:
Fukumitsu N, Ishii K, Kimura Y, Oda K, Sasaki T, Mori Y, Ishiwata K.
Imaging of adenosine A1 receptors in the human brain by positron
emission tomography with [11C]MPDX.
Ann Nucl Med. 2003; 17(6): 511-515.
Fukumitsu N, Ishii K, Kimura Y, Oda K, Sasaki T, Mori Y, Ishiwata K.
Adenosine A1 receptor mapping of the human brain by PET with8-dicyclopropylmethyl-1-11C-methyl-3-propylxanthine.
J Nucl Med. 2005; 46(1): 32-37.
Kimura Y, Ishii K, Fukumitsu N, Oda K, Sasaki T, Kawamura K, Ishiwata K.
Quantitative analysis of adenosine A1 receptors in human brain
using positron emission tomography and
[1-methyl-11C]8-dicyclopropylmethyl-1-methyl-3-propylxanthine.
Nucl Med Biol. 2004; 31(8): 975-981.
