b2plasma - tpcclib 0.7.9 © 2022 by Turku PET Centre
Convert blood time-activity curve (TAC) collected during a PET study
to plasma TAC, based on tracer-dependent population-based
RBC/plasma or plasma/blood ratio functions over time.
Usage: b2plasma [Options] tracer bloodfile HCr plasmafile
Options:
-Log
Log information is saved in output file.
-h, --help
Display usage information on standard output and exit.
-v, --version
Display version and compile information on standard output and exit.
-d[n], --debug[=n], --verbose[=n]
Set the level (n) of debugging messages and listings.
-q, --quiet
Suppress displaying normal results on standard output.
-s, --silent
Suppress displaying anything except errors.
The following human PET tracer TACs can be converted:
AH690
ratio is assumed to follow a population average curve.
AH691
ratio is assumed to follow a population average curve.
Carfentanil
ratio is assumed to follow a population average curve
(unpublished measurements from eight 70-min PET studies).
FBPA
ratio is assumed to rise from zero with slope 0.00888
(unpublished measurement from 10 subjects).
FDG
ratio is assumed to be 0.8 in the beginning and to rise with
slope 0.0012/min (Phelps ME et al. Ann Neurol 1979;6:371-388).
FDOPA
ratio is assumed to follow equation R(t)=(Rmax*t)/(Th+t),
where Rmax=1.446 and Th=83.56 (unpublished results).
Flu[mazenil]
ratio is assumed to follow an average curve based on two
subjects with assumed HCR=0.43.
FLUORIDE
ratio is assumed to be 1.23 in the beginning and to decrease slowly
with slope 0.00123/min (Hawkins et al., JNM 1992;33:633-642.).
FMPEP-D2
ratio is assumed to follow a population average curve.
FTHA
concentration in red blood cells is assumed to be zero.
MEAIB
ratio is assumed to rise from zero with slope 0.00398
(unpublished measurement from 7 subjects).
Metomidate or MTO
concentration is the same in RBC and plasma water.
ORM-B
ratio is assumed to follow a population average curve
(unpublished measurement from 6 subjects studied twice).
Palm[itate]
ratio is assumed to follow a population average curve
(unpublished measurement from 8 subjects).
PBR28HAB, PBR28MAB, PBR28LAB
ratio is assumed to follow a binding-type specific population average
curve (unpublished measurements from 90-min PET studies).
PE2I
ratio is assumed to follow a population average curve
(unpublished measurements from ten 70-min PET studies).
PIB or 6OHBTA1
ratio is assumed to follow a population average curve,
currently based on 15 subjects.
PK11195
ratio is assumed to follow a curve based on one
subject with measured HCr.
SMW139
ratio is assumed to follow a population average curve,
currently based on 11 subjects.
For mice and rats (these conversion do not utilize hematocrit):
MOUSEFDG1
plasma-to-blood ratio is assumed to follow the function published by
Yu AS et al. J Nucl Med 2009;50(6):966-973.
MOUSEFDG2
plasma-to-blood ratio is assumed to follow the function published by
Huang et al. J Nucl Med 2017;58(4):611-616.
RATFDG
plasma-to-blood ratio is assumed to follow the function published by
Weber et al. Eur J Nucl Med 2002;29(3):319-323.
Codes for tracers that have below mentioned properties:
norbc
concentration in red blood cells is assumed to be zero.
inwater
concentration is the same in RBC and plasma water.
Times must be in minutes in data files, or seconds, if appropriately
specified inside the file.
The hematocrit (HCr, HCT) is normally between 0.40-0.51 in men and 0.36-0.47
in women. Note that HCr is lower in small vessels in tissue.
Example: estimate plasma curve from measured FDG blood TAC:
b2plasma FDG i3344ab.kbq 0.38 i3344ap.kbq
See also: p2blood, b2rbc, bpr2cpr, taccalc, taccat, fit_bpr, p2bfuncs
Keywords: input, modelling, simulation, blood, plasma, RBC, hematocrit