p2blood - tpcclib 0.7.3 © 2019 by Turku PET Centre

Convert plasma time-activity curve (TAC) collected during a PET study
to blood TAC, based on tracer-dependent population-based
RBC/plasma or plasma/blood ratio functions over time.
 
Usage: p2blood [Options] tracer plasmafile HCr bloodfile
 
Options:
 -Log
     Log information is saved in output file.
 -h, --help
     Display usage information on standard output and exit.
 -v, --version
     Display version and compile information on standard output and exit.
 -d[n], --debug[=n], --verbose[=n]
     Set the level (n) of debugging messages and listings.
 -q, --quiet
     Suppress displaying normal results on standard output.
 -s, --silent
     Suppress displaying anything except errors.
 
The following human PET tracer TACs can be converted:
  AH690
     ratio is assumed to follow a population average curve.
  AH691
     ratio is assumed to follow a population average curve.
  Carfentanil
     ratio is assumed to follow a population average curve
     (unpublished measurements from eight 70-min PET studies).
  FBPA
     ratio is assumed to rise from zero with slope 0.00888
     (unpublished measurement from 10 subjects).
  FDG
     ratio is assumed to be 0.8 in the beginning and to rise with
     slope 0.0012/min (Phelps ME et al. Ann Neurol 1979;6:371-388).
  FDOPA
     ratio is assumed to follow equation R(t)=(Rmax*t)/(Th+t),
     where Rmax=1.446 and Th=83.56 (unpublished results).
  Flu[mazenil]
     ratio is assumed to follow an average curve based on two
     subjects with assumed HCR=0.43.
  FLUORIDE
     ratio is assumed to be 1.23 in the beginning and to decrease slowly
     with slope 0.00123/min (Hawkins et al., JNM 1992;33:633-642.).
  FMPEP-D2
     ratio is assumed to follow a population average curve.
  FTHA
     concentration in red blood cells is assumed to be zero.
  MEAIB
     ratio is assumed to rise from zero with slope 0.00398
     (unpublished measurement from 7 subjects).
  Metomidate or MTO
     concentration is the same in RBC and plasma water.
  ORM-B
     ratio is assumed to follow a population average curve
     (unpublished measurement from 6 subjects studied twice).
  Palm[itate]
     ratio is assumed to follow a population average curve
     (unpublished measurement from 8 subjects).
  PBR28HAB, PBR28MAB, PBR28LAB
     ratio is assumed to follow a binding-type specific population average
     curve (unpublished measurements from 90-min PET studies).
  PE2I
     ratio is assumed to follow a population average curve
     (unpublished measurements from ten 70-min PET studies).
  PIB or 6OHBTA1
     ratio is assumed to follow a population average curve,
     currently based on 15 subjects.
  PK11195
     ratio is assumed to follow a curve based on one
     subject with measured HCr.
For mice and rats (these conversion do not utilize hematocrit):
  MOUSEFDG1
     plasma-to-blood ratio is assumed to follow the function published by
     Yu AS et al. J Nucl Med 2009;50(6):966-973.
  MOUSEFDG2
     plasma-to-blood ratio is assumed to follow the function published by
     Huang et al. J Nucl Med 2017;58(4):611-616.
  RATFDG
     plasma-to-blood ratio is assumed to follow the function published by
     Weber et al. Eur J Nucl Med 2002;29(3):319-s323.
 
Codes for tracers that have below mentioned properties:
  norbc
     concentration in red blood cells is assumed to be zero.
  inwater
     concentration is the same in RBC and plasma water.
 
Times must be in minutes in data files, or seconds, if appropriately
specified inside the file.
 
The hematocrit (HCr, HCT) is normally between 0.40-0.51 in men and 0.36-0.47
in women. Note that HCr is lower in small vessels in tissue.
 
Example: estimate blood curve from measured FDG plasma TAC:
     p2blood FDG i3344ap.kbq 0.38 i3344ab.kbq
 
See also: b2plasma, b2rbc, bpr2cpr, taccalc, dftcat, fit_bpr
 
Keywords: input, modelling, simulation, blood, plasma, RBC, hematocrit