Convert plasma time-activity curve (TAC) collected during a PET study to blood TAC, based on tracer-dependent population-based RBC/plasma or plasma/blood ratio functions over time. Usage: p2blood [Options] tracer plasmafile HCr bloodfile Options: -Log Log information is saved in output file. -h, --help Display usage information on standard output and exit. -v, --version Display version and compile information on standard output and exit. -d[n], --debug[=n], --verbose[=n] Set the level (n) of debugging messages and listings. -q, --quiet Suppress displaying normal results on standard output. -s, --silent Suppress displaying anything except errors. The following human PET tracer TACs can be converted: AH690 ratio is assumed to follow a population average curve. AH691 ratio is assumed to follow a population average curve. Carfentanil ratio is assumed to follow a population average curve (unpublished measurements from eight 70-min PET studies). FBPA ratio is assumed to rise from zero with slope 0.00888 (unpublished measurement from 10 subjects). FDG ratio is assumed to be 0.8 in the beginning and to rise with slope 0.0012/min (Phelps ME et al. Ann Neurol 1979;6:371-388). FDOPA ratio is assumed to follow equation R(t)=(Rmax*t)/(Th+t), where Rmax=1.446 and Th=83.56 (unpublished results). Flu[mazenil] ratio is assumed to follow an average curve based on two subjects with assumed HCR=0.43. FLUORIDE ratio is assumed to be 1.23 in the beginning and to decrease slowly with slope 0.00123/min (Hawkins et al., JNM 1992;33:633-642.). FMPEP-D2 ratio is assumed to follow a population average curve. FTHA concentration in red blood cells is assumed to be zero. MEAIB ratio is assumed to rise from zero with slope 0.00398 (unpublished measurement from 7 subjects). Metomidate or MTO concentration is the same in RBC and plasma water. ORM-B ratio is assumed to follow a population average curve (unpublished measurement from 6 subjects studied twice). Palm[itate] ratio is assumed to follow a population average curve (unpublished measurement from 8 subjects). PBR28HAB, PBR28MAB, PBR28LAB ratio is assumed to follow a binding-type specific population average curve (unpublished measurements from 90-min PET studies). PE2I ratio is assumed to follow a population average curve (unpublished measurements from ten 70-min PET studies). PIB or 6OHBTA1 ratio is assumed to follow a population average curve, currently based on 15 subjects. PK11195 ratio is assumed to follow a curve based on one subject with measured HCr. SMW139 ratio is assumed to follow a population average curve, currently based on 11 subjects. UCB-J ratio is assumed to follow a population average curve, currently based on 7 subjects. For mice and rats (these conversion do not utilize hematocrit): MOUSEFDG1 plasma-to-blood ratio is assumed to follow the function published by Yu AS et al. J Nucl Med 2009;50(6):966-973. MOUSEFDG2 plasma-to-blood ratio is assumed to follow the function published by Huang et al. J Nucl Med 2017;58(4):611-616. RATFDG plasma-to-blood ratio is assumed to follow the function published by Weber et al. Eur J Nucl Med 2002;29(3):319-s323. Codes for tracers that have below mentioned properties: norbc concentration in red blood cells is assumed to be zero. inwater concentration is the same in RBC and plasma water. Times must be in minutes in data files, or seconds, if appropriately specified inside the file. The hematocrit (HCr, HCT) is normally between 0.40-0.51 in men and 0.36-0.47 in women. Note that HCr is lower in small vessels in tissue. Example: estimate blood curve from measured FDG plasma TAC: p2blood FDG i3344ap.kbq 0.38 i3344ab.kbq See also: b2plasma, b2rbc, bpr2cpr, taccalc, taccat, fit_bpr, p2bfuncs Keywords: input, modelling, simulation, blood, plasma, RBC, hematocrit

This program comes with ABSOLUTELY NO WARRANTY. This is free software, and you are welcome

to redistribute it under GNU General Public License.

Source codes are available in https://gitlab.utu.fi/vesoik/tpcclib.git.