b2t_mo2 - tpcclib 0.7.4 © 2019 by Turku PET Centre

Simulation of PET tissue time-radioactivity concentration curve (TTAC)
in skeletal muscle [O-15]O2 PET studies from decay corrected arterial blood
[O-15]O2 and [O-15]H2O curves (oxygen and water BTACs).
The compartmental model for [O-15]O2 in skeletal muscle is:
 
      Blood         Muscle                 
  _______________________________________  
 |           K1 |                        | 
 |    O    ---------->  O   +  O -Mb     | 
 |     2   <----------   2      2        | 
 |             k2                        | 
 |              |        | k3            | 
 |              |        V               | 
 |           K1 |                        | 
 |    H O  ---------->  H O              | 
 |     2   <----------   2               | 
 |              | K1/pH2O                | 
 |______________|________________________| 
 
Model definitions:
  K1=perfusion (f, mL/min/dL), OER=k3/(k2+k3),
  Ki=f*OER (mL/min/dL), and
  Metabolic rate of oxygen MRO2=Ki*[O2]a (mmol/min/dL)
 
Usage: b2t_mo2 [options] obtacfile wbtacfile f OER ttacfile
 
Options:
 -sub | -nosub
     TACs of sub-compartments are written (-sub)
     or not written (-nosub, default) into the output file.
 -add
     Simulated TACs are added to an existing tissue data file.
     By default, existing file is overwritten.
 -Vb=<Blood volume (%)>
     Set the simulated blood volume; default is 3.5%.
 -Af=<Arterial proportion (%)>
     Set the simulated arterial proportion of total blood volume;
     default is 30%.
 -pH2O=<value>
     Set the partition coefficient of water; default is 0.99.
 -K1k2=<value>
     Set the K1/k2 for oxygen; by default the K1/k2 is estimated from
     OER and saturation curves for hemoglobin and myoglobin.
 -Sao2=<value>
     Saturation of arterial blood hemoglobin; default is 0.97.
 -p50Hb=<value>
     Half-saturation pressure for hemoglobin; default is 3.6 kPa.
 -p50Mb=<value>
     Half-saturation pressure for myoglobin; default is 0.319 kPa.
 -nHb=<value>
     Hill coefficient for hemoglobin; default is 2.7.
 -Mb=<value>
     Concentration of myoglobin in muscle; default is 4.7 mg/g.
 -Hb=<value>
     Concentration of hemoglobin in blood; default is 150 mg/g.
 -fpt
     Blood flow (perfusion) is assumed to be given per perfusable tissue
     volume excluding vascular volume. TTAC will still be simulated per
     regional PET volume including vascular volume.
 -voiname=<text>
     Enter a name (1-6 chars without spaces) for the simulated TTAC.
 -venao=<filename>
     Save the simulated venous [O-15]O2 BTAC
 -venaw=<filename>
     Save the simulated venous [O-15]H2O BTAC
 -h, --help
     Display usage information on standard output and exit.
 -v, --version
     Display version and compile information on standard output and exit.
 -d[n], --debug[=n], --verbose[=n]
     Set the level (n) of debugging messages and listings.
 -q, --quiet
     Suppress displaying normal results on standard output.
 -s, --silent
     Suppress displaying anything except errors.
 
For accurate results, input BTACs should be noiseless and have very
short sampling intervals. Simulated curves can thereafter be interpolated
to represent PET frames using program simframe.
Calculated tissue activities are written in the specified file with
these data columns. Columns 2-6 will be saved optionally (-sub):
  0) Time
  1) Total regional radioactivity concentration (2+3+4+5+6)
  2) Labelled [O2] component of TTAC
  3) Labelled [H2O] component of TTAC
  4) Arterial BTAC component of TTAC
  5) Venous labelled [O2] component of TTAC
  6) Venous labelled [H2O] component of TTAC
 
References:
1. Nuutila P, Peltoniemi P, Oikonen V, Larmola K, Kemppainen J, Takala T,
   Sipila H, Oksanen A, Ruotsalainen U, Bolli GB, Yki-Jarvinen H.
   Enhanced stimulation of glucose uptake by insulin increases
   exercise-stimulated glucose uptake in skeletal muscle in humans: studies
   using [15O]O2, [15O]H2O, [18F]fluoro-deoxy-glucose, and positron emission
   tomography. Diabetes 2000; 49:1084-1091.
2. Oikonen V, Nuutila P, Sipila H, Tolvanen T, Peltoniemi P, Ruotsalainen U.
   Quantification of oxygen consumption in skeletal muscle with PET and
   oxygen-15 bolus. Eur J Nucl Med. 1998; 25: 1151.
3. Oikonen V. Modelling of low oxygen consumption. In: J. Knuuti, J. Rinne,
   P.Tenhonen (ed.), Medical Applications of Cyclotrons VIII. Abstracts of
   the VIII Symposium on the Medical Applications of Cyclotrons.
   Annales Universitatis Turkuensis D346:16, 1999.
 
See also: fit_mo2, o2metab, o2_p2w, fit_o2bl, sim_o2bl, tacadd, simframe
 
Keywords: TAC, simulation, modelling, oxygen, skeletal muscle