fitmbf 2.3.0 © 1999-2013 by Turku PET Centre

Estimates the myocardial flow, alpha (PTF) and Va using Iida's MBF model (1, 2) as represented in (3) from radiowater PET studies. The same method is applied in Carimas, and for clinical work use of Carimas is recommended; however, it is possible to save regional TACs in Carimas or other sofware and used with this programs. Parameters for the program: 1) Regional TAC datafile (DFT or PMOD format) 2) Beta value (from [O-15]CO study) 3) Name of LV in TAC datafile 4) Name of whole myocardium in TAC datafile 5) Result file (5) Options: -fA[lpha] Alpha is constrained to the Alpha estimate from a previous study (in basal conditions); option -F is obligatory with this. -fVa Va is constrained to the Va estimate from a previous study (in basal conditions); option -F is obligatory with this. -F=<Result file of basal study> Alpha and/or Va is constrained regionally to the estimate that is found in this result file. -SD[=<y|N>] Standard deviations are calculated and saved in results (y), or not calculated (N, default). Program runs a lot faster if SD and CL are not calculated. -CL[=<y|N>] 95% Confidence limits are calculated and saved in results (y), or not calculated (N, default). -Ca[=<filename>] Save arterial concentration curves, by default adding .ca to filename for regional TACs. -fit=<Filename> Fitted regional TACs are written in ASCII data file. -svg=<Filename> Fitted and measured TACs are plotted in specified SVG file (6). -rd=<y|n> Correction for physical decay is removed from the measured data during model calculation (y) or not removed (n, default). This may produce more accurate results when time frames are relatively long. -h or --help Print this message and exit -v, --version or --build Print software build information and exit --silent Program works silently, printing only error and warning messages --verbose Program prints more information about what it is doing. Examples: 1. Calculation with no constraints: fitmbf s2345.dft 0.91 'lv Pl06' 'whole' s2345.res 2. Alpha (PTF) is constrained to estimates from basal study: fitmbf s2346.dft 0.91 'lv Pl05' whole s2346.res -fA -F=s2345.res Existing result files are overwritten! References: 1. Iida H, Rhodes CG, de Silva R, Yamamoto Y, Araujo LI, Maseri A, Jones T. Myocardial tissue fraction - correction for partial volume effects and measure of tissue viability. J Nucl Med 1991; 32:2169-2175. 2. Iida H, Rhodes CG, de Silva R, Araujo LI, Bloomfield P, Lammertsma AA, Jones T. Use of the left ventricular time-activity curve as a noninvasive input function in dynamic oxygen-15-water positron emission tomography. J Nucl Med 1992; 33:1669-1677. 3. Oikonen V. Model equations for myocardial perfusion studies with [15O]H2O PET. http://www.turkupetcentre.net/reports/tpcmod0005.pdf 4. File format specification: DFT. http://www.turkupetcentre.net/formats/format_dft_1_0_0.pdf 5. File format specification: Result file. http://www.turkupetcentre.net/formats/format_res_1_0_0.pdf 6. Scalable Vector Graphics (SVG) 1.1 Specification. http://www.w3.org/TR/SVG/ 7. Carimas. http://www.turkupetcentre.fi/carimas See also: b2m_mbf, fit_h2o, dftunit, rescoll, res2html Keywords: myocardium, perfusion, modelling, DFT This program comes with ABSOLUTELY NO WARRANTY. This is free software, and you are welcome to redistribute it under GNU General Public License.