2008-09-22 Vesa Oikonen, Kaisa Liukko

• TPC
• Simulation
• Analysis
• Modeling
• Tracers
• Software
• Vocabulary

This page is obsolete: please read the new version.

Simulation of regional PET TACs

Software for simulation

• 3-tissue compartment model with plasma input
  • Compartments in series
  • Compartments in parallel
• 3-tissue compartment model with plasma input considering blood volume
  • Compartments in series
  • Compartments in parallel
• 2-tissue compartment model with reference tissue input
  • Full reference tissue model
  • Simplified reference tissue model
  • Reduced reference tissue model (k₄=0)
  • Transport limited reference tissue model
• Dedicated models for PET tracers or targets
  • [¹⁵O]H₂O
  • [¹⁵O]H₂O in myocardium
  • [¹⁵O]O₂ in skeletal muscle
  • [¹⁸F]FDOPA
  • [¹⁸F]FETNIM
• 2-tissue compartment model with k_Loss
• Shape analysis method

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References:

Chen K, Huang S, Feng D. New estimation methods that directly use the time accumulated counts in the input function in quantitative dynamic PET studies. Phys. Med. Biol. 1994; 39: 2073-2090.

Coxson PG, Salmeron EM, Huesman RH, Mazoyer BM. Simulation of compartmental models for kinetic data from a positron emission tomograph. Comput. Methods Progr. Biomed. 1992; 37: 205-214.

Huang S, Bahn MM, Phelps ME. A new technique for solving nonlinear differential equations encountered in modeling of neuroreceptor-binding ligands. IEEE Trans. Nucl. Sci. 1988; 35(1): 762-766.

Kuwabara H, Cumming P, Reith J, Léger G, Diksic M, Evans AC, Gjedde A. Human striatal L-DOPA decarboxylase activity estimated in vivo using 6[¹⁸F]fluoro-DOPA and positron emission tomography: error analysis and application to normal subjects. J. Cereb. Blood Flow Metab. 1993; 13: 43-56.

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