Models for simulation of regional PET TTACs
Software for simulation
Compartmental models with plasma input
- 3-tissue compartment model: sim_3tcm for simulating
optionally more than one TTACs at the same time, with parameters in a text file;
or p2t_3c and p2t_v3c for simulating one TTAC with parameters on command-line.
- 4-tissue compartment model with dual-input and/or kLoss
Models with 1- or 2-tissue compartments can be simulated simply by setting the rate constants that apply to the second or third compartment to zero.
For demonstration purposes Excel worksheets are available for the simulation of
These programs and worksheets use the direct ODE solutions for discrete-time data. There really is no reason to use the convolution method for simulations, but programs and convexpf are available for that purpose.
2-tissue compartment model with reference tissue input
- Full reference tissue model
- Simplified reference tissue model
- Reduced reference tissue model (k4=0)
- Transport limited reference tissue model
Dedicated models for PET tracers or targets
- [15O]H2O in myocardium
- [15O]H2O in liver
- General [15O]H2O model: b2t_h2o or sim_h2o
- [15O]O2 in skeletal muscle
- [18F]FDOPA (outdated)
- [18F]FETNIM (outdated)
Program simshape can be used to simulate regional TTAC using shape analysis method.
- Parameters for simulation
- Input for simulations
- Adding noise to simulated data
- Compartmental models
- Analysis of regional TAC data
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Updated at: 2019-10-25
Created at: 2010-09-20
Written by: Vesa Oikonen