Models for simulation of regional PET TTACs
Software for simulation
Compartmental models with plasma input
- 3-tissue compartment model: sim_3tcm for simulating
optionally more than one TTACs at the same time, with parameters in a text file;
or p2t_3c and p2t_v3c for simulating one TTAC with parameters on command-line.
- 4-tissue compartment model with dual-input and/or kLoss
Models with 1- or 2-tissue compartments can be simulated simply by setting the rate constants that apply to the second or third compartment to zero.
For demonstration purposes Excel worksheets are available for the simulation of
2-tissue compartment model with reference tissue input
- Full reference tissue model
- Simplified reference tissue model
- Reduced reference tissue model (k4=0)
- Transport limited reference tissue model
Dedicated models for PET tracers or targets
- [15O]H2O in myocardium
- [15O]O2 in skeletal muscle
- [18F]FDOPA (outdated)
- [18F]FETNIM (outdated)
Program simshape can be used to simulate regional TTAC using shape analysis method.
- Parameters for simulation
- Input for simulations
- Adding noise to simulated data
- Compartmental models
- Analysis of regional TAC data
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Coxson PG, Huesman RH, Borland L. Consequences of using a simplified kinetic model for dynamic PET data. J Nucl Med. 1997; 38: 660-667.
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Kuwabara H, Cumming P, Reith J, Léger G, Diksic M, Evans AC, Gjedde A. Human striatal L-DOPA decarboxylase activity estimated in vivo using 6[18F]fluoro-DOPA and positron emission tomography: error analysis and application to normal subjects. J Cereb Blood Flow Metab. 1993; 13: 43-56.
Created at: 2010-09-20
Updated at: 2018-01-18
Written by: Vesa Oikonen