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Oxygen labelled tracers: arterial blood input

Required corrections

"Blood pump" data

Researcher has to do the following corrections to arterial blood data collected using an on-line detector ("blood pump") (*.alg, *.bld or *.blo.lis), before using it as the input in his/her data analyses:

  1. Processing of raw data, calibration and correction for radioactive decay to the radiotracer injection time
  2. Correction for dispersion in the "blood pump" assembly and possibly in vasculature
  3. The difference between the tracer arrival times to tissue (PET measurement) and blood sampling site ("blood pump") must be corrected (delay correction). Result of delay time correction must always be controlled visually!
  4. [15O]O2 studies may additionally require a metabolite correction. However, some model analysis software make these corrections automatically; look for the specific analysis program documentation).

Manual blood samples

Manual blood samples are pre-processed by the personnel of blood laboratory, and the necessary corrections for manually sampled blood and plasma TACs are made to the data before the datafiles are copied to the PETO system or directory S:\Lab\plasma\ for use. This applies currently to all [15O]CO blood TACs and [15O]O2 plasma TACs.

Software for processing blood data

MS Windows in TPC network

These software are available for use in Windows XP in computers connected to TPC intranet. Installation to independent computers is possible but not supported.

Solaris or outside TPC network

These low-level software are available for use in Sun/PC Solaris in computers connected to TPC intranet, and can be downloaded and installed to other computers as well.



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