fitkloss 3.0.2 © 2002-2013 by Turku PET Centre

Non-linear fitting of two-tissue compartment model with kLoss or k4 to plasma and tissue time-activity curves (TACs) to estimate K1, k2, k3, kLOSS or k4, and optionally Vb. kLoss-model: ____ ____ ____ | Ca | K1 | | k3 | | |____| ----> | C1 | ----> | C2 | | | <---- |____| | | | Cv | k2 | | | | kLoss | | |____| <----------------- |____| k4-model: ____ ____ ____ | Ca | K1 | | k3 | | |____| ----> | C1 | ----> | C2 | | Cv | <---- | | <---- | | |____| k2 |____| k4 |____| Parameters: 1) Plasma file (corrected for labeled metabolites) 2) Blood file 3) Tissue TAC file 4) Fit end time (duration) 5) Result file Options: -lim[=<filename>] Specify the constraints for model parameters; This file with default values can be created by giving this option as the only command-line argument to this program. Without filename the default values are printed on screen. -SD[=<y|N>] Standard deviations are calculated and saved in results (y), or not calculated (N, default). Program runs a lot faster if SD and CL are not calculated. -CL[=<y|N>] 95% Confidence limits are calculated and saved in results (y), or not calculated (N, default). -model=<k4|kloss> Specify the model that is fitted to data; kLoss model by default. -Vb=<Vb(%)> Enter a fixed vascular blood volume Vb; fitted by default. -f=<K1/F> K1/F-ratio; by default flow is ignored (F>>K1). -a=<fA%> Arterial volume fraction; 30 by default; effective only with -f. -fit=<Filename> Fitted regional TACs are written in DFT format. -svg=<Filename> Fitted and measured TACs are plotted in specified SVG file. -h or --help Print this message and exit --version or --build Print software build information and exit --silent Program works silently, printing only error and warning messages --verbose Program prints more information about what it is doing. Example: fitkloss s919ap.dat s919ab.dat s919.dft 999 s919.res If datafile contains weights, those are used in the fitting. Model parameters are written in the specified result file. See also: dftweigh, fitk4, fitk3, patlak, logan, p2t_loss, dft2svg, rescoll Keywords: TAC, modelling, loss rate, enzyme activity This program comes with ABSOLUTELY NO WARRANTY. This is free software, and you are welcome to redistribute it under GNU General Public License.

GNU GPL

Last updated 2014-07-10 15:46:29