fitkloss 3.0.2 © 2002-2013 by Turku PET Centre

Non-linear fitting of two-tissue compartment model with kLoss or k4 to plasma and tissue time-activity curves (TACs) to estimate K1, k2, k3, kLOSS or k4, and optionally Vb. kLoss-model: ____ ____ ____ | Ca | K1 | | k3 | | |____| ----> | C1 | ----> | C2 | | | <---- |____| | | | Cv | k2 | | | | kLoss | | |____| <----------------- |____| k4-model: ____ ____ ____ | Ca | K1 | | k3 | | |____| ----> | C1 | ----> | C2 | | Cv | <---- | | <---- | | |____| k2 |____| k4 |____| Parameters: 1) Plasma file (corrected for labeled metabolites) 2) Blood file 3) Tissue TAC file 4) Fit end time (duration) 5) Result file Options: -lim[=<filename>] Specify the constraints for model parameters; This file with default values can be created by giving this option as the only command-line argument to this program. Without filename the default values are printed on screen. -SD[=<y|N>] Standard deviations are calculated and saved in results (y), or not calculated (N, default). Program runs a lot faster if SD and CL are not calculated. -CL[=<y|N>] 95% Confidence limits are calculated and saved in results (y), or not calculated (N, default). -model=<k4|kloss> Specify the model that is fitted to data; kLoss model by default. -Vb=<Vb(%)> Enter a fixed vascular blood volume Vb; fitted by default. -f=<K1/F> K1/F-ratio; by default flow is ignored (F>>K1). -a=<fA%> Arterial volume fraction; 30 by default; effective only with -f. -fit=<Filename> Fitted regional TACs are written in DFT format. -svg=<Filename> Fitted and measured TACs are plotted in specified SVG file. -h or --help Print this message and exit --version or --build Print software build information and exit --silent Program works silently, printing only error and warning messages --verbose Program prints more information about what it is doing. Example: fitkloss s919ap.dat s919ab.dat s919.dft 999 s919.res If datafile contains weights, those are used in the fitting. Model parameters are written in the specified result file. See also: dftweigh, fitk4, fitk3, patlak, logan, p2t_loss, dft2svg, rescoll Keywords: TAC, modelling, loss rate, enzyme activity This program comes with ABSOLUTELY NO WARRANTY. This is free software, and you are welcome to redistribute it under GNU General Public License.


Last updated 2014-07-10 15:46:29