Hepatic blood flow using [15O]H2O and dynamic PET
[15O]H2O bolus model
The analysis method of hepatic blood flow (actually perfusion) is based on one-tissue compartment model, modified to account for the dual input of the liver, consisting of hepatic artery and portal vein (Taniguchi et al., 1993, 1996, and 1999; Kudomi et al., 2008; Slimani et al., 2008; Kiss et al., 2009; Rijzewijk et al., 2010). Although appropriate radiowater model for liver requires both inputs, it does not necessarily mean that the portal perfusion (fPV) can be reliably quantitated, especially in non-invasive studies where tracer concentration curve of portal vein is not measured but estimated in the model (Ziegler et al., 1996; Becker et al., 2005).
Perfusion in liver tumours can be analyzed using only arterial input, because most of the blood supply for tumours is supplied by the portal artery (Yamaguchi et al., 2000; Kunishima et al., 2002; Fukuda et al., 2004). Steady-state approach should be applied, because the partition coefficient of water in tumours is not known (Yamaguchi et al., 2000).
Arterial blood data
Blood data from online sampler
Arterial blood data, collected using on-line sampling system, must be calibrated and corrected for physical decay, dispersion, and time delay. It is recommended that regional tissue TAC from the liver is used in time delay correction.
Extraction of arterial blood data from PET image
Instead of using ABSS, arterial blood TAC can be extracted from the dynamic image. The procedure is very reliable if CT or MR images are available and the point spread function of PET image is known (full width at half maximum FWHM in mm). If no CT or MR images are available, then the program eabaort may need to be validated for the specific PET scanner. With modern PET scanners the image resolution is good enough for using the blood TAC from small ROI drawn into abdominal aorta without any correction for partial volume effect.
Delay correction may not be needed for arterial input that is extracted from abdominal aorta, but for the portal vein input estimation the delay is an important parameter.
Analysis method in TPC
Software for analysis of [15O]H2O PET data is currently not available in TPC, but analyses are performed by N Kudomi. The method has also been used by Rijzewijk et al. (2010).
- Dual blood supply to the liver
- Radiowater model
- ARG method
- Powerpoint presentation by Lotfi Slimani
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Created at: 2015-02-04
Updated at: 2018-12-01
Written by: Vesa Oikonen