Model calculation for regional TTACs

Regional tissue time-activity curves are less noisy than data from individual image voxels, enabling application of more complex analysis techniques than with dynamic PET images.

Common analysis methods for TTACs

Models for reversible tracer uptake

Outcome is the volume of distribution, binding potential, or a related parameter.

Without blood sampling

With metabolite corrected plasma input

Models for irreversible tracer uptake

Outcome is the Ki, FUR, k3, or a related parameter, representing metabolic rate (MR), or enzyme or transporter activity.

Without blood sampling

With metabolite corrected plasma input

Standardized uptake values

Miscellaneous utility software for regional modeling


See also:



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Created at: 2007-09-26
Updated at: 2016-07-19
Written by: Vesa Oikonen