On-line blood sampling with 11C and 18F tracers
Required corrections for the blood pump data
Researcher has to do the following corrections to arterial blood data collected using an on-line detector ("blood pump") (*.alg, *.bld or *.blo.lis), before using it as the input in his/her data analyses:
- Processing of raw data, calibration and correction for radioactive decay
- Blood curve must be converted to plasma
After the "blood pump" data is converted to plasma TAC, it usually has to be combined with the plasma TAC measured from manual blood samples. This can be accomplished withdftcat. There is often an overlap in "blood pump" and manual samples, and in those cases dftcat will automatically ignore the end of pump data. Otherwise, those overlapping samples must be selected and removed manually in a text editor.
When you have the combined plasma TAC, you can proceed with the pre-processing of the input curve as usual (Producing blood/plasma TACs for model calculations):
- Metabolite correction of the plasma curve is required for most of the tracers.
- The difference between the tracer arrival times to tissue (PET measurement) and blood sampling site ("blood pump") may have to be corrected (delay correction).
Software or scripts available only in Windows XP in TPC network
Calibration, decay correction, plasma metabolite correction, and time delay correction for:
Inside TPC, if you are using MS Explorer, you can execute the scripts either from command-line, or by using the links below:
Low-level software (available on both Solaris and Windows)
- Processing on-line detector data, calibration and decay correction: blo2kbq
- Applying or removing decay correction: dftdecay
- Dispersion correction: disp4dft
- Time delay correction: fitdelay
- Manual delay correction: dfttime
- Converting blood TACs to plasma TACs: b2plasma
See example on handling on-line detector data.
