2007-09-26 Vesa Oikonen, Kaisa Sederholm

This page is obsolete: please read the new version.

Model calculation for regional TACs

General analysis methods for TACs

Reversible models (Distribution volume and Receptor binding potential)
- Without blood sampling
  - Reference tissue compartment models
  - Logan plot analysis
  - Tissue/Reference tissue and (Tissue-Reference tissue)/Reference tissue: dftratio
- With metabolite corrected blood curve
  - Full compartmental model fit
  - Compartmental model fit with fixed K₁/k₂
  - Logan plot analysis
  - Late-scan tissue/plasma ratio; may correlate with DV
Irreversible models (Enzyme or transporter activity)
- Without blood sampling
- With metabolite corrected blood curve
Standardized uptake values (SUV)
% of injected dose / g of tissue (%i.d./g): dftsuv

Detailed procedures for analysis of regional TACs

[¹⁵]H₂O: Perfusion (blood flow)
- Dynamic [¹⁵O]H₂O study of brain, muscle, or tumour
- Dynamic [¹⁵O]H₂O study of heart
[¹¹C]MP4B: BuChE activity in the brain (k₃)
[¹⁵O]O₂: Oxygen consumption
- Skeletal muscle
- Brain
List by tracer

Utility software for regional modeling

Correction of blood radioactivity in regional TACs: dftcbv
Correction of recovery and spill-over in myocardial TACs: heartcor
Calculation of bound curve (Bound=Total-Reference): dftbound
Calculation of tissue-to-plasma ratio
Simulation tools
Plotting of TACs and fitted curves

Further calculations and processing for results of regional analysis

Regional analysis results are saved in specific result format. There is software for further calculations and processing of these result files.